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Hyaluronan fragments act as an endogenous danger signal by engaging TLR2.
Upon tissue injury, high m.w. hyaluronan (HA), a ubiquitously distributed extracellular matrix component, is broken down into lower m.w. (LMW) fragments, which in turn activate an innate immune response. In doing so, LMW HA acts as an endogenous danger signal alerting the immune system of a breach in tissue integrity. In this report, we demonstrate that LMW HA activates the innate immune respon...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2016
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.3383