Ethical issues of randomized controlled trials
نویسندگان
چکیده
منابع مشابه
Ethical issues in naturalistic versus controlled trials
Ethical core issues in research with human subjects are related to informed consent and risk-benefit assessment. This is valid for all types of studies. However, there has been much greater focus of ethical considerations on controlled clinical trials than on naturalistic trials, probably because the former are interventional in nature and may have unknown and perhaps severe somatic risks, wher...
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In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
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The use of control group in clinical trials has been universally acclaimed by researchers to effectively help discriminate between the actual effects of an intervention and those arising from other factors. However, the choice of the control that provided both scientific and ethical acceptability among researchers has been a source of intense debate. We conducted a literature search on the use ...
متن کاملEthical issues posed by cluster randomized trials in health research
The cluster randomized trial (CRT) is used increasingly in knowledge translation research, quality improvement research, community based intervention studies, public health research, and research in developing countries. However, cluster trials raise difficult ethical issues that challenge researchers, research ethics committees, regulators, and sponsors as they seek to fulfill responsibly thei...
متن کاملEthical issues in pragmatic randomized controlled trials: a review of the recent literature identifies gaps in ethical argumentation
BACKGROUND Pragmatic randomized controlled trials (RCTs) are designed to evaluate the effectiveness of interventions in real-world clinical conditions. However, these studies raise ethical issues for researchers and regulators. Our objective is to identify a list of key ethical issues in pragmatic RCTs and highlight gaps in the ethics literature. METHODS We conducted a scoping review of artic...
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ژورنال
عنوان ژورنال: Bangladesh Journal of Bioethics
سال: 2014
ISSN: 2078-1458,2226-9231
DOI: 10.3329/bioethics.v5i1.18441