Ethical Issues in Neonatal and Pediatric Clinical Trials
نویسندگان
چکیده
منابع مشابه
Clinical trials in neonates: ethical issues.
If neonates are to receive the best possible treatment, they must be involved in clinical trials. However, doing such trials raises complicated ethical issues. These issues are not unique to neonatology but some are more common or acute than in other areas of medicine. In practice, two particular issues -- equipoise and informed consent -- arise as many different types of problem. The question ...
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Ethical reasons are presented for requiring 1) that a proposal for a clinical trial should be accompanied by a thorough review of all previous trials that have examined the same and closely related questions, and 2) that a trial should be approved by a research ethics committee only if the investigator undertakes to register it in an appropriate register of clinical trials as soon as one exists.
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BACKGROUND: Chemoprevention of malignancy is a new concept in clinical medicine, and little is written about the ethics of identifying and enrolling eligible subjects in chemoprevention clinical trials. METHODS: The authors identify the ethical issues raised in the conduct of clinical chemoprevention trials and review the ethical considerations that should guide clinical researchers in the desi...
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The vertical transmission trials conducted in a variety of developing countries by researchers from more developed countries illustrate a variety of crucial ethical issues. Three crucial issues are the injustice of the use of placebo control groups, the coerciveness of the offer to participate, and the exploitation of Third World countries. This paper examines each of these issues separately. I...
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In Rep.ply:-I would like to thank Ilrs. Introna and Blair for making several interesting comments regarding the reported case of vagotonia and cardiac arrest during a spind anesthetic. I agree that in most individuals the sympathetic and parasympathetic systems remains remarkably balanced, despite significant blockade of the sympathetic afferent and efferent pathways during spinal anesthesia. O...
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ژورنال
عنوان ژورنال: Pediatric Clinics of North America
سال: 2012
ISSN: 0031-3955
DOI: 10.1016/j.pcl.2012.07.007