Ethanol-paired stimuli can increase reinforced ethanol responding
نویسندگان
چکیده
منابع مشابه
Effects of ethanol withdrawal on ethanol-reinforced responding in rhesus monkeys.
Rhesus monkeys self-administered ethanol intravenously during daily, 3-h sessions. When ethanol-reinforced responding was stable and ethanol intake was in the range of 2.6-3.6 g/kg/3 h, physiological dependence to ethanol was induced by daily passive infusions of additional ethanol. In less than 1 week, mild to moderate withdrawal signs were observed prior to daily sessions. Ethanol intake was ...
متن کاملThe reinforcing property of ethanol in the rhesus monkey. I. Initiation, maintenance and termination of intravenous ethanol-reinforced responding.
Monkeys self-administer pharmacologically significant amounts of alcohol only under certain circumstances.8 For example, Deneau and colleagues' used a method that permitted a rhesus monkey to voluntarily self-administer ethanol solution through an indwelling venous catheter. They found that three of five monkeys initiated and maintained response-contingent deliveries of ethanol at a dose of 200...
متن کاملConditioned effects produced by naltrexone doses that reduce ethanol-reinforced responding in rhesus monkeys.
Clinical trials have shown that naltrexone is effective in treating alcohol dependence; nausea and dysphoria have been reported as "side effects" in many of these studies. In primates, naltrexone reduces reinforced responding for oral ethanol, sucrose, and phencyclidine. This study was designed to determine if naltrexone reduces reinforced responding for various solutions by producing an intero...
متن کاملA behavioral economic analysis of concurrent ethanol- and water-reinforced responding in different preference conditions.
BACKGROUND The reinforcing properties of orally self-administered drugs have been evaluated by using choice procedures. The preference for the drug over a nondrug alternative has indicated that the drug has greater value than the nondrug alternative as a reinforcer at some drug concentrations. However, at large drug concentrations, the fluid deliveries of the drug may be equal to or less than t...
متن کاملOperant responding for ethanol in rats with a long-term history of free-choice ethanol drinking.
Wistar rats were allowed to drink ethanol in a two-bottle (water vs 2-8% v/v ethanol) and then in a three-bottle choice paradigm (water vs 8% ethanol vs 16% ethanol, v/v). After 7 months of free access to alcohol, the subjects were trained to respond for 8% ethanol in an operant procedure. No relationship was found between prior alcohol drinking and lever pressing for ethanol.
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ژورنال
عنوان ژورنال: Alcohol
سال: 2020
ISSN: 0741-8329
DOI: 10.1016/j.alcohol.2019.10.007