Estrogens Induce Expression of Membrane-Associated Estrogen Receptor α Isoforms in Lactotropes
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Estrogens Induce Expression of Membrane-Associated Estrogen Receptor α Isoforms in Lactotropes
Estrogens are key to anterior pituitary function, stimulating hormone release and controlling cell fate to achieve pituitary dynamic adaptation to changing physiological conditions. In addition to their classical mechanism of action through intracellular estrogen receptors (ERs), estrogens exert rapid actions via cell membrane-localized ERs (mERs). We previously showed that E2 exerts a rapid pr...
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It is well known that cardiovascular disease is less frequent in premenopausal women compared with men but rises rapidly in postmenopausal women. Such early observations led to the hypothesis that estrogen therapy will reduce the risk of postmenopausal women developing cardiovascular disease.1 However, observational studies have led to conflicting results, with some studies reporting reductions...
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Ad Addr dr res es ess s s fo fo for r Co Co orr rr rre es espo po pond nd nde ence ce e: : : Professor Al Al lex ex exan an ande de der r r Bo Bo Bobi b k k k
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Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0041299