Estrogen receptor (ER) beta , a modulator of ERalpha in the uterus

Estrogen receptor (ER) b, a modulator of ERa in the uterus

Many of the effects of estrogens on the uterus are mediated by ERa, the predominant ER in the mature organ. Because of the poor reproductive capacity of ERb knockout (BERKO) female mice (small litter size, multiple-resorbed fetuses), the role of uterine ERb was explored. In the immature uterus, ERa and ERb are expressed at comparable levels in the epithelium and stroma, and 17b-estradiol (E2) t...

ESR 2 ( Estrogen Receptor 2 ( ER beta ) )

Estrogen Receptor Beta Expression in Melanomas Versus Dysplastic Nevi

Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...

Effects of SERM (selective estrogen receptor modulator) treatment on growth and proliferation in the rat uterus

BACKGROUND Selective estrogen receptor modulators (SERMs) have been developed in order to create means to control estrogenic effects on different tissues. A major drawback in treatment of estrogen receptor (ER) positive breast cancer with the antagonist tamoxifen (TAM) is its agonistic effect in the endometrium. Raloxifene (RAL) is the next generation of SERMs where the agonistic effect on the ...

A comparative study of estrogen receptor beta expression in melanoma and benign melanocytic lesions

Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 w...