ESTRO ACROP guidelines for target volume definition in pancreatic cancer

Despite of the predominant role chemotherapy and surgery in pancreatic ductal adenocarcinoma (PDAC), radiotherapy (RT) still has a place multimodal management this disease where local tumour sequelae are fatal about 40% patients. RT (chemoradiotherapy stereotactic body radiotherapy) is used investigated non-metastatic setting as part definitive treatment strategies, (neo)adjuvant settings for locally recurrent disease. The ACROP committee was delegated by ESTRO to recommend target volume delineation these clinical situations. guidelines document result structured evaluation best available evidence panel international experts field. Guidance planning including diagnostic imaging provided. Recommendations given GTV delineation. definition CTV volumes critically discussed. Aspects motion patient positioning taken into account PTV definition. Furthermore, aspects organs at risk dose constraints described both, standard hypofractionated, settings. This guideline purpose support standardised optimised processes practice prospective studies.