Estimation of Small, Dense LDL Particles Using Equations Derived From Routine Lipid Parameters as Surrogate Markers
نویسندگان
چکیده
منابع مشابه
Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering.
Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level. An optical technique using dynamic light scattering (DLS) measurement is useful for point-of-care testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions i...
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15 صفحه اولSmall, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress.
OBJECTIVE The relationship of the structural and functional heterogeneity of HDL particles to protection of LDL against oxidative stress is indeterminate. METHODS AND RESULTS HDL subfractions of defined physicochemical properties were isolated by density gradient ultracentrifugation from normolipidemic human serum (n=8), and their capacity to protect LDL from oxidation was evaluated. Under mi...
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BACKGROUND Recent clinical studies showed that lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a predictor for incident atherosclerotic disease. We have previously shown that among the LDL subfractions, Lp-PLA(2) activity is preferentially associated with the atherogenic small, dense (sdLDL) particles in vitro. We investigated whether Lp-PLA(2) could be a marker of sdLDL in human plasm...
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The relation between plasma lipoproteins and atherosclerosis has evolved over the past fifty years. Serum cholesterol levels were shown to be associated with coronary artery disease (CAD) in familial hypercholesterolemia in the early 20 century (see Frederickson1). This cholesterol was determined to be in a particular lipoprotein class2 now termed low-density lipoprotein (LDL) cholesterol.3 LDL...
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ژورنال
عنوان ژورنال: Biochemistry & Analytical Biochemistry
سال: 2014
ISSN: 2161-1009
DOI: 10.4172/2161-1009.1000146