Estimation of Serum Thyroid Stimulating Hormone and Anti-Thyroid Antibodies as Biomarkers of Malignancy in Thyroid Nodule Patients

نویسندگان

چکیده

Aim: To find out association of Serum Thyroid Stimulating Hormone (TSH) and Anti-Thyroid Antibodies (ATA) i.e., anti Tg-Ab & TPO-Ab with thyroid carcinoma in nodule patients presented Mayo Hospital Lahore. Study design: It was a comparative cross-sectional study. Methods: wasconducted Biochemistry Department Biomedical Sciences KEMU, Lahore from February 2018 to May 2019. Seventy were included the study based on selection criteria data recorded preformed questionnaire. The participants classified into benign (n=36) malignant categories (n=34) histopathological radiological investigations. levels TSH anti- antibodies (TPO-Ab&Tg-Ab) measured employing ELISA (Enzyme Linked Immunosorbent Assay) technique. Results: nodules found be more prevalent females (n=64, 91.4%). mean age subjects 38.46±12.92 years there significant older (p=0.001). Moreover, TSH, Anti-Tg-Ab higher than significantly associated cancer (p=<0.05). Furthermore, binary logistic regression analysis concluded that serum may increase risk malignancy (OR=5.124). Conclusion: Older showed patients. Keywords: carcinoma, stimulating hormone, Anti- thyroglobulin Antibody, Anti-TPO antibodies,

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ژورنال

عنوان ژورنال: Pakistan Journal of Medical and Health Sciences

سال: 2022

ISSN: ['1996-7195']

DOI: https://doi.org/10.53350/pjmhs20221611177