ESTIMATION OF MINIMUM INHIBITORY CONCENTRATION OF ANTIBIOTICS USING MICRO-TITER PLATE METHOD FOR NATIVE MULTI DRUG RESISTANT GRAM NEGATIVE BACTERIA

Efficacy of Amikacin and Imipenem Against Multi-Drug Resistant Gram-Negative Bacteria Isolated From Wound Infections

Background and Objective: Gram-negative pathogens are considered the common cause of wound infections associated with increased mortality and morbidity rates. Antibiotics combination has been used to overcome this problem. Aims: In this study, we identify Gram-negative pathogens found in wound infections and assess the in-vitro efficacy of a combination of amikacin and imipenem against the resi...

Novel Immunization Strategies Against Multi-drug-resistant Gram-negative Bacteria

Gradient Plate for Hicomb Minimum Inhibitory Concentration (MIC) Test

Abstract Background and objectives: "The comb antibiotic sensitivity test" is a quick, reliable and cost effective method to determine the susceptibility of bacteria to different antibiotics. The purpose of this study is to design a plate that is easy and quick to use, and enable to be interpreted easily without the need for measurement of the margins with a ruler. Material and Method...

An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria.

OBJECTIVES An orthogonal approach taken towards novel antibacterial drug discovery involves the identification of small molecules that potentiate or enhance the activity of existing antibacterial agents. This study aimed to identify natural-product rifampicin adjuvants in the intrinsically resistant organism Escherichia coli. METHODS E. coli BW25113 was screened against 1120 actinomycete ferm...

Activities of selected medicinal plants against multi-drug resistant Gram-negative bacteria in Cameroon.

BACKGROUND Medicinal plants are used worldwide for several human ailments including bacterial infections. The present work was designed to assess the in vitro antibacterial activities of some Cameroonian medicinal plants including Entada abyssinica, Entada africana, Pentaclethra macrophylla, Allexis cauliflora, Anthocleista leibrechtsiana, Carapa procera, Carica papaya and Persea americana agai...