Estimation of Benchmark Dose of Cumulative Cadmium Exposure for Renal Tubular Effect
نویسندگان
چکیده
منابع مشابه
Benchmark Dose for Cadmium-Induced Renal Effects in Humans
OBJECTIVES Our goal in this study was to explore the use of a hybrid approach to calculate benchmark doses (BMDs) and their 95% lower confidence bounds (BMDLs) for renal effects of cadmium in a population with low environmental exposure. METHODS Morning urine and blood samples were collected from 820 Swedish women 53-64 years of age. We measured urinary cadmium (U-Cd) and tubular effect marke...
متن کاملBenchmark Dose Estimation for Cadmium-Induced Renal Tubular Damage among Environmental Cadmium-Exposed Women Aged 35–54 Years in Two Counties of China
BACKGROUND A number of factors, including gender, age, smoking habits, and occupational exposure, affect the levels of urinary cadmium. Few studies have considered these influences when calculating the benchmark dose (BMD) of cadmium. In the present study, we aimed to calculate BMDs and their 95% lower confidence bounds (BMDLs) for cadmium-induced renal tubular effects in an age-specific popula...
متن کاملEffects of exposure imprecision on estimation of the benchmark dose.
In regression analysis failure to adjust for imprecision in the exposure variable is likely to lead to underestimation of the exposure effect. However, the consequences of exposure error for determination of safe doses of toxic substances have so far not received much attention. The benchmark approach is one of the most widely used methods for development of exposure limits. An important advant...
متن کاملRelations between liver cadmium, cumulative exposure, and renal function in cadmium alloy workers.
Detailed biochemical investigations of renal function were made on 75 male workers exposed to cadmium and an equal number of referents matched for age, sex, and employment status. The exposed group consisted of current and retired workers who had been employed in the manufacture of copper-cadmium alloy at a single factory in the United Kingdom for periods of up to 39 years and for whom cumulati...
متن کاملBenchmark Dose for Urinary Cadmium based on a Marker of Renal Dysfunction: A Meta-Analysis
BACKGROUND Low doses of cadmium can cause adverse health effects. Benchmark dose (BMD) and the one-sided 95% lower confidence limit of BMD (BMDL) to derive points of departure for urinary cadmium exposure have been estimated in several previous studies, but the methods to derive BMD and the estimated BMDs differ. OBJECTIVES We aimed to find the associated factors that affect BMD calculation i...
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ژورنال
عنوان ژورنال: International Journal of Environmental Research and Public Health
سال: 2021
ISSN: 1660-4601
DOI: 10.3390/ijerph18105177