Estimation accuracy under covariate-adaptive randomization procedures
نویسندگان
چکیده
منابع مشابه
Using Randomization Tests to Preserve Type I Error With Response-Adaptive and Covariate-Adaptive Randomization.
We demonstrate that clinical trials using response adaptive randomized treatment assignment rules are subject to substantial bias if there are time trends in unknown prognostic factors and standard methods of analysis are used. We develop a general class of randomization tests based on generating the null distribution of a general test statistic by repeating the adaptive randomized treatment as...
متن کاملAdaptive randomization procedures for the web-based randomization system RANDI2.
©2012 Dustri-Verlag Dr. K. Feistle ISSN 0946-1965 DOI 10.5414/CPP50085 e-pub: December 28, 2011
متن کاملTopics On Change–Point Estimation Under Adaptive Sampling Procedures
To my parents ii ACKNOWLEDGEMENTS My foremost thanks go to my advisors Dr. George Michailidis and Dr. Moulinath Banerjee. I thank them for their advice, patience, support, encouragement, insights and suggestions that helped shape my research skills. This thesis would not be possible without them. I am grateful to my two other committee members, Dr. for reviewing my work and providing me with va...
متن کاملStart-up designs for response-adaptive randomization procedures with sequential estimation.
Response-adaptive randomization procedures are appropriate for clinical trials in which two or more treatments are to be compared, patients arrive sequentially and the response of each patient is recorded before the next patient arrives. However, for those procedures that involve sequential estimation of model parameters, start-up designs are commonly required in order to provide initial estima...
متن کاملA Graphical Method for Comparing Response-Adaptive Randomization Procedures
Abstract Response-adaptive randomization procedures have a dual goal of estimating the treatment effect and randomizing patients with a higher probability of receiving the superior treatment. These are competing objectives, and no procedure in the literature is “perfect” with respect to both objectives. For clinical trials of two treatments, we discuss metrics for comparing response-adaptive ra...
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ژورنال
عنوان ژورنال: Electronic Journal of Statistics
سال: 2017
ISSN: 1935-7524
DOI: 10.1214/17-ejs1261