Estimates Of Glomerular Filtration Rate in Critically Ill Patients With Sepsis: Comparisons of Different Equations

Introduction: Accurate assessment of glomerular filtration rate (GFR) is important in the critically ill. Kinetic estimate GFR (keGFR) considers changes creatinine, creatinine production rate, and volume distribution, hence postulated to be a more accurate GFR, where there are rapidly changing kidney functions. We evaluated association estimated by established equations keGFR with clearance (CrCl) measurement. Materials Methods: This prospective observational study ill patients. Inclusion criteria were patients older than 18 years old sepsis (clinical infection increase SOFA score>2), plasma procalcitonin>0.5ng/ml. Plasma Cystatin C (CysC) measured on admission 4 hours later, eGFR calculated Cockcroft Gault (CG), MDRD, CKD-EPI equations, compared CrCl Results: A total 70 recruited. all strongly correlates CrCl. had least bias depicted mean differences nearest zero (-18ml/min). Similarly, keGFRCysC less eGFRCysC, difference -21ml/min. eGFRCG greatest precision narrower SD lines, however both not much those eGFRCG. Conclusions: In sepsis, keGFRCr fair when absence measurement, calculations useful as surrogate for function.