Esters of penicillins—are they hepatotoxic?
نویسندگان
چکیده
منابع مشابه
Assessment of hepatotoxic potential.
Philosophic concepts and pragmatic approaches toward improved understanding of the effect of drugs in the hepatocyte are reviewed. No set pattern of studies is advocated but rather observations are encouraged within the framework of studies that provide for varied exposure of the hepatocyte. Clinical usage should be imitated to provide earliest possible indications of toxicity in man. The need ...
متن کاملAssessment of hepatotoxic liabilities by transcript profiling.
Male Wistar rats were treated with various model compounds or the appropriate vehicle controls in order to create a reference database for toxicogenomics assessment of novel compounds. Hepatotoxic compounds in the database were either known hepatotoxicants or showed hepatotoxicity during preclinical testing. Histopathology and clinical chemistry data were used to anchor the transcript profiles ...
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Minocycline (25 to 100 micrograms/g) dose dependently increased serum glutamic oxalacetic transaminase, urea, and bilirubin levels, and the hepatic triglyceride content in mice. In animals pretreated with phenobarbital to enhance minocycline metabolism, the effects on liver triglycerides were attenuated, while the changes in serum glutamic oxalacetic transaminase, urea, and bilirubin were enhan...
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I . It has been suggested that carbon tetrachloride damages rat liver by accelerating processes of lipid peroxidation at subcellular sites and that the protective action of vitamin E is due to its functioning as an antioxidant in vivo. Direct evidence for these mechanisms in vivo has been sought and is critically examined. 2. The increased production of malondialdehyde by rat liver microsomal f...
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Dyslipidemia is a major risk factor for coronary heart disease (CHD), and current guidelines support low-density lipoprotein cholesterol (LDL-C) as a primary target of therapy.[1] Previous studies suggest that increasing high-density lipoprotein cholesterol (HDL-C) and reducing triglycerides and small LDL particles may also have a positive impact in prevention.[2] These factors are considered s...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1980
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/6.6.697