منابع مشابه
Establishing Transgenic Schistosomes
Draft genome sequences for Schistosoma japonicum and Schistosoma mansoni are now available. The schistosome genome encodes approximately 13,000 protein encoding genes for which the function of only a small minority is understood. The new genes represent potential intervention targets. Molecular tools are needed to determine the importance of these new genes. There is a role for transgenesis in ...
متن کاملPaving the way for transgenic schistosomes.
In parasitological research, significant progress has been made with respect to genomics and transcriptomics but transgenic systems for functional gene analyses are mainly restricted to the protozoan field. Gene insertion and knockout strategies can be applied to parasitic protozoa as well as gene silencing by RNA interference (RNAi). By contrast, research on parasitic helminthes still lags beh...
متن کاملINFECTION wirn SCHISTOSOMES
The proportion of ail cancers represented by urinary bladder cancer varies greatly wi thin Africa and the Middle East, and the ratio of male to female frequency of occurrence is nearly as variable (Parkin, 1986). ln Egyt, the proportion of bladder cancers among aIl cancers in men is twce that in Zambia, four times that in Zimbabwe and 10 times that in Algeria. Very few formai assessments of the...
متن کاملTRP channels in schistosomes
Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this fact, only a few classes of parasitic helm...
متن کاملSchistosomes, snails and satellites.
This paper gives an overview of the recent progress made in the use and application of geographical information systems (GIS) and remotely sensed (RS) satellite sensor data for the epidemiology and control of schistosomiasis in sub-Saharan Africa. Details are given of the use of GIS to collate, map and analyse available parasitological data. The use of RS data to understand better the broad sca...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2011
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001230