Establishing a hematopoietic genetic network through locus-specific integration of chromatin regulators

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Establishing a hematopoietic genetic network through locus-specific integration of chromatin regulators.

The establishment and maintenance of cell type-specific transcriptional programs require an ensemble of broadly expressed chromatin remodeling and modifying enzymes. Many questions remain unanswered regarding the contributions of these enzymes to specialized genetic networks that control critical processes, such as lineage commitment and cellular differentiation. We have been addressing this pr...

متن کامل

Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.

The hematopoietic transcription factor GATA-1 regulates erythropoiesis and beta-globin expression. Although consensus GATA-1 binding sites exist throughout the murine beta-globin locus, we found that GATA-1 discriminates among these sites in vivo. Conditional expression of GATA-1 in GATA-1-null cells recapitulated the occupancy pattern. GATA-1 induced RNA polymerase II (pol II) recruitment to s...

متن کامل

Oncogene interference through targeting of chromatin regulators

The chromatin regulatory machinery is often exploited during tumorigenesis. For example, many of the central transcription factors in cancer biology (such as p53 and Myc) utilize chromatin regulators (CRs) as coactivators or corepressors to regulate their downstream target genes. Moreover, somatic mutation of CR-encoding genes is a common driver mechanism seen in many cancer types. Hence, CRs o...

متن کامل

Locus-Specific Biochemical Epigenetics/Chromatin Biochemistry by Insertional Chromatin Immunoprecipitation

Comprehensive understanding of regulation mechanisms of biological phenomena mediated by functions of genomic DNA requires identification of molecules bound to genomic regions of interest in vivo. However, nonbiased methods to identify molecules bound to specific genomic loci in vivo are limited. To perform biochemical and molecular biological analysis of specific genomic regions, we developed ...

متن کامل

Wireless sensor network design through genetic algorithm

In this paper, we study WSN design, as a multi-objective optimization problem using GA technique. We study the effects of GA parameters including population size, selection and crossover method and mutation probability on the design. Choosing suitable parameters is a trade-off between different network criteria and characteristics. Type of deployment, effect of network size, radio communication...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2013

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1302771110