Esmolol acutely alters oxygen supply-demand balance in exercising muscles of healthy humans
نویسندگان
چکیده
منابع مشابه
Right ventricular oxygen supply/demand balance in exercising dogs.
This is the first investigation of right ventricular (RV) myocardial oxygen supply/demand balance in a conscious animal. A novel technique developed in our laboratory was used to collect right coronary (RC) venous blood samples from seven instrumented, conscious dogs at rest and during graded treadmill exercise. Contributions of the RV oxygen extraction reserve and the RC flow reserve to exerci...
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Early studies of ranolazine centered on reductions in myocardial oxygen demand produced by partial inhibition of fatty acid oxidation, particularly as free fatty acid levels increase locally during ischemic episodes. More recent studies report that this mechanism is unlikely to be operative at the plasma levels of ranolazine associated with beneficial clinical effect. A reduction in myocardial ...
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To ensure that tissues are well oxygenated, oxygen supply and demand are now targets of therapy for the critically ill patient. This chapter reviews the physiologic determinants of oxygen supply, how it is threatened by respiratory or cardiac dysfunction or by hemorrhaged or anemic states, and how it can be assessed in individual patients. Activities and conditions that increase tissue oxygen d...
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Although large doses of epinephrine increase coronary perfusion pressure and flow during cardiopulmonary resuscitation, epinephrine also increases myocardial oxygen consumption during ventricular fibrillation. To test the hypothesis that epinephrine improves the balance between myocardial oxygen supply and demand during cardiopulmonary resuscitation, myocardial adenosine 5'-triphosphate (ATP) a...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2018
ISSN: 2051-817X
DOI: 10.14814/phy2.13673