Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play
نویسندگان
چکیده
منابع مشابه
Molecular and Evolutionary Bases of Within-Patient Genotypic and Phenotypic Diversity in Escherichia coli Extraintestinal Infections
Although polymicrobial infections, caused by combinations of viruses, bacteria, fungi and parasites, are being recognised with increasing frequency, little is known about the occurrence of within-species diversity in bacterial infections and the molecular and evolutionary bases of this diversity. We used multiple approaches to study the genomic and phenotypic diversity among 226 Escherichia col...
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Large-scale bacterial genome sequencing efforts to date have provided limited information on the most prevalent category of disease: sporadically acquired infections caused by common pathogenic bacteria. Here, we performed whole-genome sequencing and de novo assembly of 312 blood- or urine-derived isolates of extraintestinal pathogenic (ExPEC) Escherichia coli, a common agent of sepsis and comm...
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Most human extraintestinal Escherichia coli infections, including those involving antimicrobial resistant strains, are caused by the members of a limited number of distinctive E. coli lineages, termed extraintestinal pathogenic E. coli (ExPEC), that have a special ability to cause disease at extraintestinal sites when they exit their usual reservoir in the host's intestinal tract. Multiple line...
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background: Infections due to Extraintestinal pathogenic Escherichia coli (ExPEC) represent a major but little-appreciated health threat. Proper antibiotic sensitivity testing and judicious use of antibiotics are crucial in treatment of such infections. Aims: This study was done to determine the spectrum of infections caused by ExPEC and their antimicrobial susceptibility pattern. settings and ...
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ژورنال
عنوان ژورنال: mSphere
سال: 2021
ISSN: 2379-5042
DOI: 10.1128/msphere.01176-20