Esch. coli endocarditis successfully treated with oral trimethoprim and sulphamethoxazole.

Esch. coli endocarditis successfully treated with oral trimethoprim and sulphamethoxazole.

A 42-year-old patient was successfully treated for subacute bacterial endocarditis due to Esch. coli with oral trimethoprim and sulphamethoxazole. The treatment lasted nine months and was continued through a period of cholestatic jaundice superimposed on hepatic damage due to subacute bacterial endocarditis. There were no toxic effects attributable to the two antibacterials despite their prolon...

Bacterial endocarditis over prosthetic valves treated with trimethoprim-sulphamethoxazole combination.

During the past few years a number of reports have indicated the therapeutic effectiveness of the new synthetic chemotherapeutic agent trimethoprim (2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine) used in combination with sulphamethoxazole in a wide range of bacterial infections (Noall, Sewards, and Waterworth, i962; Schneider et al., i965; Akinkugbe et al., I968; Hughes, I969). Staphylococc...

Acute brucellosis treated with trimethoprim and sulphamethoxazole.

Four patients with acute brucellosis are described, none of whom had any connexion with farming or milk industry, the source of infection being different in each case. The diagnosis was made by serological tests, and in three of the four cases was confirmed by positive cultures from bone marrow (one case) and liver biopsy (two cases). Treatment with the combination of trimethoprim/sulphamethoxa...

Esch. coli septicaemia treated with ampicillin.

Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli.

The activity of trimethoprim (TMP) and sulphamethoxazole (SMX), alone and in combination, against a sensitive strain of Escherichia coli was investigated in turbidimetric systems. In a static system in which the conditions of exposure of bacteria to drug resembled those of conventional minimum inhibitory concentration (MIC) titrations, both TMP and SMX exhibited antibacterial activity at concen...