ESAT-6–dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo

ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo.

IFN-γ is a critical mediator of host defense against Mycobacterium tuberculosis (Mtb) infection. Antigen-specific CD4+ T cells have long been regarded as the main producer of IFN-γ in tuberculosis (TB), and CD4+ T cell immunity is the main target of current TB vaccine candidates. However, given the recent failures of such a TB vaccine candidate in clinical trials, strategies to harness CD4-inde...

Recent Advances in EMG Pattern Recognition for Prosthetic Control

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

Analysis of mycobacterial strains that have lost their ability to cause disease is a powerful approach to identify yet unknown virulence determinants and pathways involved in tuberculosis pathogenesis. Two of the most widely used attenuated strains in the history of tuberculosis research are Mycobacterium bovis BCG (BCG) and Mycobacterium tuberculosis H37Ra (H37Ra), which both lost their virule...

pattern recognition in maintenance data using methodologies data minitng (cade study isfahan regional power electric company)

فعالیت های نگهداری و تعمیرات اطلاعاتی را تولید می کند که می تواند در تعیین زمان های بیکاری و ارایه یک برنامه زمان بندی شده یا تعیین هشدارهای خرابی به پرسنل نگهداری و تعمیرات کمک کند. وقتی که مقدار داده های تولید شده زیاد باشند، فهم بین متغیرها بسیار مشکل می شوند. این پایان نامه به کاربردی از داده کاوی برای کاوش پایگاه های داده چندبعدی در حوزه نگهداری و تعمیرات، برای پیدا کردن خرابی هایی که موجب...

Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis.

Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides imm...