Erythropoietin Stimulates Tumor Growth via EphB4

Does Erythropoietin Promote Tumor Growth?

In Response: We appreciate Yoon and colleagues’ interest in our report and welcome the opportunity to reply to their comments. Our study was designed in a context in which several clinical trials, including patients with head and neck squamous cell carcinomas, breast cancer, non–small cell lung cancer and nonmyeloid malignancies, showed a potential deleterious effect of recombinant human erythr...

Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E

Recombinant human erythropoietin (EPO) is standard treatment for anemia in cancer patients. Recent clinical trials suggest that EPO may accelerate tumor progression and increase mortality. However, the evidence supporting a growth-promoting effect of EPO has remained controversial. Employing an in vivo model of B16 murine melanoma, we observed that administration of EPO to tumor bearing C57BL/6...

Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth.

Receptor tyrosine kinases of the Eph family are up-regulated in different types of cancer. EphB4 and its ligand ephrin-B2 have been linked to breast cancer, but little is known about how this receptor-ligand complex may contribute to oncogenesis. The Eph receptors transmit forward signals via their kinase domain and reverse signals via their transmembrane ephrin-B ligands. Therefore, we used Ep...

e Marrow and Stimulates Solid Tumor Growth

Download cular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis physiologic and pathologic conditions. Recently, Flt-1–expressing cells were reported to contribute to racranial growth of glioma cells. However, the role of Flt-1 signaling in solid tumor growth in s.c. tissue t been elucidated. To investigate how Flt-1 signaling is involved in t...

Constitutively Activated Erythropoietin Receptor Stimulates