Erratum: DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
نویسندگان
چکیده
منابع مشابه
Heterogeneity of Signal Transducer and Activator of Transcription Binding Sites in the Long-Terminal Repeats of Distinct HIV-1 Subtypes
HIV-1 can be subdivided into distinct subtypes; the consequences of such a genomic variability remain largely speculative. The long terminal repeats (LTR) control HIV transcription and reflect the major differences of distinct viral subtypes. Three regions in the HIV-1 subtype B LTR are close matches to the Signal Transducer and Activator of Transcription (STAT) consensus sequence. Here, we sho...
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Alignments of homologous genomic sequences are widely used to identify functional genetic elements and study their evolution. Most studies tacitly equate homology of functional elements with sequence homology. This assumption is violated by the phenomenon of turnover, in which functionally equivalent elements reside at locations that are nonorthologous at the sequence level. Turnover has been d...
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and last paragraph of the intro, The claim that this is a new mechanism of retrotransposon regulation by transcription start site control is not true. The authors are apparently unaware of the work by David Garfinkel's lab on Ty1. Saha et al identified a downstream TSS that expresses a protein that inhibits Ty1 (Journal of Virology 2015, Jan 21). The downstream TSS is regulated by a subunit of ...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2017
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1117-1661c