Ergosterol biosynthesis inhibition: a target for antifungal agents.
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چکیده
منابع مشابه
Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate.
The thiocarbamate antimycotics tolnaftate and tolciclate blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. There was no inhibition of other steps in ergosterol biosynthesis. In whole Candida cells, ergosterol biosynthesis inhibition was ...
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Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis. To date, these transcriptional responses have been shown to be dependent on the presence of the azoles and/or depletion of ergosterol. Using an inducible promoter to regulate Neurospora crassa erg11, which encodes th...
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Ergosterol, the major sterol of fungal membranes, is essential for developmental growth and the main target of antifungals that are currently used to treat fatal fungal infections. Emergence of resistance to existing antifungals is a current problem and several secondary resistance mechanisms have been described in Aspergillus fumigatus clinical isolates. A full understanding of ergosterol bios...
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We performed a genomewide screen for altered sensitivity to antifungal drugs, including clotrimazole and terbinafine, that target ergosterol biosynthesis using a Schizosaccharomyces pombe gene deletion library consisting of 3,004 nonessential haploid deletion mutants. We identified 109 mutants that were hypersensitive and 11 mutants that were resistant to these antifungals. Proteins whose absen...
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aneous and followed a reversible competitive mechanism in S/reptonivc~e.s p. and a reversible non-competitive mechanism in N . erythropo1i.s and S . wt t i t t i i t t i e . An irreversible type of inhibition was observed for 1'. lestostcrorii cholesterol oxid a se . T h e fit o f thc inhibition profile o f cyclic amines with cholesterol oxidases and AS A'-isomerases offers a fungicide screenin...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 1995
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.1995_4900