ERBB2 oncogenicity: ERBIN helps to perform the job

ERBB2 oncogenicity: ERBIN helps to perform the job

ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) is an oncogenic tyrosine kinase receptor that is overexpressed in breast cancer. Antibodies and inhibitors targeting ERBB2 are currently available, although therapeutic failures remain frequent. We discuss here recent data showing that the scaffold protein ERBB2IP (ERBB2 interacting protein, best known as ERBIN) regulates E...

Randomization helps to perform independent tasks reliably

This paper is about algorithms that schedule tasks to be performed in a distributed failure-prone environment, when processors communicate by message-passing, and when tasks are independent and of unit length. The processors work under synchrony and may fail by crashing. Failure patterns are imposed by adversaries. The question how the power of adversaries affects the optimality of randomized a...

Randomization Helps to Perform Tasks on Processors Prone to Failures

Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction.

Erbin, a binding partner of ErbB2, was identified as the first member of the LAP family of proteins. Erbin was shown at postsynaptic membranes of the neuromuscular junction (NMJ) or in cultured C2C12 myotubes (1) to be concentrated, (2) to regulate the Ras-Raf-Mek pathway, and (3) to inhibit TGF-beta signaling. In the CNS, Erbin interacts with PSD-95. Furthermore, agrin-MuSK signaling initiates...

Randomization Helps to Perform Tasks on Pro essors Prone to Failures