EP.TH.37Radioembolization with yttrium-90 microspheres for management of breast liver metastases: a systematic review and pooled analysis

Abstract Aims Radioembolization with yttrium-90 microspheres is an emerging option for management of liver metastases breast cancer when other systemic therapies have failed. The aims this systematic review were to assess the effect radioembolization on i) tumour response and ii) patient survival post -radioembolization. Methods was performed using Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). A literature search PubMed EMBASE databases from January 2007 December 2019. initial yielded 265 reports which potentially suitable inclusion in review. Studies published English reporting at least one outcome interest considered be inclusion. Conference abstracts; case reports, animal studies not excluded Results final number met criteria 12 (n = 452 patients). There no randomized controlled trials identified. age patients included ranged 52 61 years. duration follow-up 6 15.7 months. total confined 236 (52.2%). Cumulative analysis revealed that conferred control rate 81% patients. Overall post-radioembolization 3.6 20.9 months estimated mean 11.3 Conclusion ytrrium-90 appears confer growth most patients, however its need elucidated further.