Epoxides as microsomal metabolites of polycyclic hydrocarbons
نویسندگان
چکیده
منابع مشابه
Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens.
K-region epoxides of the carcinogens benz[a] anthracene, dibenz[a,h]anthracene, and 7-methylbenz[a] anthracene are mutagenic in strains of Salmonella typhimurium designed to detect frameshift mutagens. Parent hydrocarbons, K-region diols and phenols and some other epoxides are inactive as mutagens in these tests. Polycyclic hydrocarbon epoxides, and other presumed proximal carcinogens, are disc...
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Ingestion is an important exposure route for polycyclic aromatic hydrocarbons (PAHs) to enter the human body. Although the formation of hazardous PAH metabolites by human biotransformation enzymes is well documented, nothing is known about the PAH transformation potency of human intestinal microbiota. Using a gastrointestinal simulator, we show that human intestinal microbiota can also bioactiv...
متن کاملAlbumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons.
We investigated the utility of adducts formed by the reaction of the naphthalene metabolites naphthalene-1,2-oxide, 1,2-naphthoquinone (1,2-NPQ), and 1,4-naphthoquinone (1,4-NPQ) with serum albumin (Alb) as biomarkers of exposure to polycyclic aromatic hydrocarbons. Cysteinyl serum Alb adducts of 1,2- and 1,4-NPQ (1,2-NPQ-Alb and 1,4-NPQ-Alb, respectively) but not of naphthalene-1,2-oxide were ...
متن کاملTransformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons.
K-region epoxides of dibenz(a,h)anthracene and benz(a)anthracene were more active in producing malignant transforma tion of hamster embryo cells than the corresponding hydrocarbons, K-regions CMand frans-dihydrodiols and phenols. The cytotoxicity exerted by epoxides, relative to the other derivatives, varied among those tested. The 8,9-epoxide (non-K-region) of benz(a)anthracene was less active...
متن کاملReactions of 'K'-region epoxides of polycyclic hydrocarbons with nucleic acids and polyribonucleotides.
'K'-region epoxides have been detected as microsomal metabolites of the polycyclic hydrocarbons phenanthrene and benz[a]anthracene (Grover et al., 1971b), of pyrene and benzo[a]pyrene (Grover et al., 1972) and of 7,12-dimethylbenz[a]anthracene (Keysell et al., 1972). Synthetic 'K'-region epoxides have been found to possess biological activity as mutagens (Huberman et al., 1971; Cookson et al., ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1971
ISSN: 0014-5793
DOI: 10.1016/0014-5793(71)80411-8