Epithelial–mesenchymal transition in prostate cancer: providing new targets for therapy
نویسندگان
چکیده
منابع مشابه
New targets for resistant prostate cancer
Although prostate cancer (PCa) initially responds to standard luteinizing hormone releasing hormone agonist–based androgen-deprivation therapy (ADT), most advanced, lethal PCa eventually becomes castrationresistant PCa (CRPC) and metastasizes to bone [1]. The use of second generation anti–androgen receptor (AR) agents, i.e., abiraterone and enzalutamide (ENZ), has resulted in modestly increased...
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NEDD9 belongs to the Cas (Crk-associated substrate) family, proteins of which mediate downstream signaling processes including cell-cycle, tumorigenesis and cytoskeletal organization. In epithelial-mesenchymal transition (EMT), NEDD9 plays an important role, but the functional mechanism underlying NEDD9-mediated EMT in prostate cancer (PCa) remains uncertain. Recently we confirmed that NEDD9 is...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2011
ISSN: 1008-682X,1745-7262
DOI: 10.1038/aja.2010.169