Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

Abstract Background The purpose of this study is to evaluate the influence anti-vascular endothelial growth factor (VEGF) in appearance or progression epiretinal membranes (ERMs) age-related macular degeneration (ARMD) and investigate confounding factors causing ERMs. Methods Seventy-six eyes that were treated for more than 36 months from first anti-VEGF injection assessed. Binary logistic regression analysis was performed between smoking, lens status, subretinal hemorrhage, posterior vitreous detachment (PVD) peripheral retinal degeneration, type AMD, conditions contralateral eye, number injections as independent variables ERMs during dependent variables. Results presence vitreomacular adhesion (VMA) development PVD observation period significantly associated (Odds ratio [OR]: 5.77; 95% confidence interval [CI], 1.72–19.4; p = 0.005) with Moreover, (OR: 3.87; CI, 1.15–13.0; 0.029). Injection not 1.02; 0.90–1.16; 0.72). Conclusion This suggests possibilities alone are unable cause ERMs, VMA developing has a prior impact on ARMD similar idiopathic degenerations both related pathogenesis ARMD.