Epiphyseal Chondrocyte Secondary Ossification Centers Require Thyroid Hormone Activation of Indian Hedgehog and Osterix Signaling
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چکیده
منابع مشابه
The role of secondary ossification centers in the management of epiphyseal and apophyseal fractures
The site where bone begins to form in the shaft of a long bone or the body of an irregular bone is called a primary ossification center. The site where bone formation continues after beginning in the long shaft or body of the bone, usually in an epiphysis is a secondary ossification center. A secondary ossification center is the center of bone formation appearing later than the punctum ossifica...
متن کاملHedgehog Signaling in Endochondral Ossification
Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator. Among three Hh proteins in mammals, Indian hedgehog (Ihh) is known to work as a major Hh input that induces biological impact of Hh si...
متن کاملActivation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage.
OBJECTIVE The objectives of this study were to (1) determine the correlation between osteoarthritis (OA) and Indian hedgehog (Ihh) expression, and (2) establish the effects of Ihh on expression of markers of chondrocyte hypertrophy and matrix metalloprotease (MMP)-13 in human OA cartilage. DESIGN OA cartilage and synovial fluid samples were obtained during total knee arthroplasty. Normal cart...
متن کاملIndian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.
Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh) and PTHrP signaling play crucial roles in regulating the onset of chondrocyte hypertrophy by forming a negative feedback loop, in which Ihh signaling regulates chondrocyte hypertrophy by ...
متن کاملMultipurpose contrast enhancement on epiphyseal plates and ossification centers for bone age assessment
BACKGROUND The high variations of background luminance, low contrast and excessively enhanced contrast of hand bone radiograph often impede the bone age assessment rating system in evaluating the degree of epiphyseal plates and ossification centers development. The Global Histogram equalization (GHE) has been the most frequently adopted image contrast enhancement technique but the performance i...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2014
ISSN: 0884-0431
DOI: 10.1002/jbmr.2256