EPILEPSY IN THE CONSANGUINEOUS FAMILIES AT TRIBAL SOCIETY OF KHYBER PAKHTUNKHWA-PAKISTAN

Consanguineous marriages are practiced worldwide but very common as social characteristic norms of the tribal society Pakistan and have reached (~63%). Couples married within blood relatives, inheriting different genetic disorders including epilepsy in their offspring.
 Objectives: The present work is ever first attempt to reaffirm association between disease (ED) consanguinity Tribal Society Khyber Pakhtunkhwa-Pakistan.
 Methodology: Approximately, 150 clinically diagnosed epileptic patients consanguineous families aging around 20 years were included. Children this study 7-10 male female ratio among was 1:1.5. target familial cases included based on sex, age, parental consanguinity, seizure type, cause epilepsy, family history. parents interviewed collect required information after informed consent. Non-consanguineous families, with acquired causes, those who not willingly participated excluded from study. 
 Results: Statistical analysis while applying Odds Ratio (OR), Z-test, Chi-Square, showed significant findings (P< 0.01). For second-degree cousins, its 95% confidence interval (CI) done. In current study, compared general population. Generally, 56 (37.33%) patient’s cousins (OR=3.245 95%-CI=2.26-4.645 P<0.0001), 24 (16.00%) (OR=3.269 95%-CI=2.032-5.258 P<0.0001) 70 (46.66%) unrelated.
 Conclusion: overall parentage (OR=3.252 95%-CI=2.345-4.510 clearly indicates potential role heritage lineage/consanguinity families.
 statistical supports counseling before marriages. More genotype-phenotype correlation also needed minimize risk disease.