Epigenetics in Toxicology

Epigenetics in Toxicology: The Implications of Epigenetic Alterations Driven by External Exposures for Human Health

Epigenetic modifications constitute a layer of information in addition to the genetic platform of information, comprising several components, such as DNA methylation, covalent histone modifications, particularly histone acetylation and methylation, and non-coding RNA-related mechanisms (Bergmann and Lane, 2003; Jenuwein and Allis, 2001; Razin and Riggs, 1980; Razin and Szyf, 1984; Strahl and Al...

The Prospects of Epigenetics in Neuroscience

Epigenetics in diagnosis of colorectal cancer

Colorectal cancer (CRC) is a third most common epithelial carcinoma. CRC is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. The use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...

The Role of Epigenetics in Cancer Drug Resistance

Cancer is caused by aberrant genetic and epigenetic changes in genes expression. DNA methylation, histone modification, and microRNAs gene deregulation are the most known epigenetic changes in different stages of cancer. Since every tumor has its own specific epigenome, any abnormal pattern is a potential biomarker for classification of different types of tumors. Despite, tumorigenesis, abnorma...

Session I-12: Epigenetics and its increasing relevance in toxicology and risk assessment Session I -12: Oral presentations

the term “epigenetics” was coined in the 1940s and denotes the heritable changes in the phenotype or gene expression patterns caused by mechanisms other than changes in the underlying DNA sequence. Since its introduction, the epigenetics research field has experienced a true boost, particularly in the last two decades, with the in-depth characterization of the determinants of the epigenome and ...