Epigenetics in the hematologic malignancies
نویسندگان
چکیده
منابع مشابه
Epigenetics in the hematologic malignancies.
A wealth of genomic and epigenomic data has identified abnormal regulation of epigenetic processes as a prominent theme in hematologic malignancies. Recurrent somatic alterations in myeloid malignancies of key proteins involved in DNA methylation, post-translational histone modification and chromatin remodeling have highlighted the importance of epigenetic regulation of gene expression in the i...
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T HE p53 HAS BEEN CHOSEN as molecule of the year for 1993 by the journal Science.' The protein's illustrious history began quietly in 1979, when a 53-kD eukaryotic protein was shown to bind to SV40 large T The protein was named p53 because of its size. Initial studies suggested that p53 was an oncogene because it could transform rodent ~ e l l s . ~ ' ~ The p53 genes used in these studies h...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2014
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2013.092007