منابع مشابه
Epigenetics and Liver Fibrosis
Liver fibrosis arises because prolonged injury combined with excessive scar deposition within hepatic parenchyma arising from overactive wound healing response mediated by activated myofibroblasts. Fibrosis is the common end point for any type of chronic liver injury including alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, and cholestatic liver diseases. Although ge...
متن کاملEpigenetics in Cardiac Health and Disease
225 miR-218 and mi-R34a drive persistent myocardial oxidative stress by targeting chromatin remodelers DNMT3b and SIRT1: new mechanistic insights in diabetic cardiomyopathy S. Costantino1; F. Paneni1; K. Mitchell2; L. Berrino3; C. Schwarzwald2; M. Volpe4; TF. Luscher5; F. Cosentino1 Karolinska Institute, Cardiology Unit, Stockholm, Sweden; University of Zurich, Veterinary physiology, Zurich, Sw...
متن کاملCardiac Fibrosis
Heart failure, the clinical manifestation of numerous forms of cardiovascular disease, is a devastating disorder characterized by interstitial fibrosis, chamber remodeling, and reduced ventricular compliance. Heart disease remains the predominant cause of mortality in the United States, accounting for nearly 800 000 deaths per year. Furthermore, it presents a considerable economic burden, with ...
متن کاملCardiac Involvement in Mild Cystic Fibrosis Lung Involvement Assessed by Tissue‐Doppler Echocardiography
Background:Cystic Fibrosis (CF) is a systemic disease affecting extra pulmonary dysfunction as a result of CF-related lung disease. Because of lack of enough studies in this field and utilization of TDE in this field, we aimed to evaluate t...
متن کاملCardiac dysfunction is attenuated by ginkgolide B via reducing oxidative stress and fibrosis in diabetic rats
Objective(s): Diabetic cardiomyopathy is a leading factor of high morbidity and mortality in diabetic patients. Our previous results revealed that ginkgolide B alleviates endothelial dysfunction in diabetic rats. This study aimed to investigate the effect of ginkgolide B on cardiac dysfunction and its mechanism in diabetic rats.Materials and Methods:<...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2018
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2018.05.003