منابع مشابه
Epigenetic regulation of hematopoiesis by DNA methylation.
During embryonic development, cell type-specific transcription factors promote cell identities, while epigenetic modifications are thought to contribute to maintain these cell fates. Our understanding of how genetic and epigenetic modes of regulation work together to establish and maintain cellular identity is still limited, however. Here, we show that DNA methyltransferase 3bb.1 (dnmt3bb.1) is...
متن کاملRegulation of hematopoiesis.
Normal hematopoiesis is a well-regulated process in which the generation of mature blood elements occurs from a primitive pluripotent stem cell in an ordered sequence of maturation and proliferation. Regulation occurs at the level of the structured microenvironment (stroma), via cell-cell interactions and by way of the generation of specific hormones and cytokines: erythropoietin, interleukin 3...
متن کاملConcise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights and Therapeutic Applications
Hematopoiesis is the process of blood cell formation starting from hematopoietic stem/progenitor cells (HSPCs). The understanding of regulatory networks involved in hematopoiesis and their impact on gene expression is crucial to decipher the molecular mechanisms that control hematopoietic development in physiological and pathological conditions, and to develop novel therapeutic strategies. An i...
متن کاملEpigenetic regulation of lineage commitment in normal and malignant hematopoiesis by histone demethylase KDM2B
Jaclyn Andricovich, Yan Kai, Weiqun Peng, Adlen Foudi, and Alexandros Tzatsos Cancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, and George Washington Cancer Center, George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA Department of Physics, George Washington University, Washington DC 20037, USA 4 INSERM UMR-S935, André Lwoff ...
متن کاملT cell regulation of hematopoiesis.
It has long been known that thymus-derived lymphocytes (T cells) can produce cytokines that have powerful effects on hematopoiesis. All major classes of T cells--CD4 T helper cells, CD4 regulatory T cells, CD8 T cells, gammadelta T cells and NKT cells--produce a number of cytokines and chemokines that can modulate hematopoiesis. More recent research has shown that specific T helper cell types, ...
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ژورنال
عنوان ژورنال: International Journal of Hematology
سال: 2012
ISSN: 0925-5710,1865-3774
DOI: 10.1007/s12185-012-1183-x