منابع مشابه
Epigenetic Regulation of Gene Expression in Keratinocytes
The nucleus is a complex and highly compartmentalized organelle, which undergoes major organization changes during cell differentiation, allowing cells to become specialized and fulfill their functions. During terminal differentiation of the epidermal keratinocytes, the nucleus undergoes a programmed transformation from active status, associated with execution of the genetic programs of cornifi...
متن کاملThe Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity
Conventional treatment for cancer such as surgical resection and chemotherapy can cause damage in cases with advanced cancers. Moreover, the identification of tumor-specific targets has great importance in T-cell therapies. For decades, T cell activity has been stimulated to improve anti-tumor activity. Bispecific antibodies have attracted strong interest from pharmaceutical companies, for thei...
متن کاملDifferent Mechanisms of Epigenetic Regulation of Gene Expression
DNA replication involves the chromatin assembly on new DNA strands which involves the formation of new nucleosomes, the basic unit of chromatin. Nucleosome is composed of the tetramer of H3/H4 histones and two dimers of histones H2A/ H2B that are wrapped around with DNA segment [1,2]. H3/ H4 and H2A/H2B histones are called core histones as they are positioned in the center of nucleosome. Some c...
متن کاملEpigenetic Regulation of Depot-Specific Gene Expression in Adipose Tissue
In humans, adipose tissue is distributed in subcutaneous abdominal and subcutaneous gluteal depots that comprise a variety of functional differences. Whereas energy storage in gluteal adipose tissue has been shown to mediate a protective effect, an increase of abdominal adipose tissue is associated with metabolic disorders. However, the molecular basis of depot-specific characteristics is not c...
متن کاملEpigenetic regulation of gene expression and cellular differentiation
Epigenome is defined by a collection of various chromatin modifications, which maintains a chromatin environment that is either permissive or inhibitory for gene expression. While association of histone modifications with expressed or silent genes has been established, it remains unclear how changes in chromatin modifications relate to changes in gene expression. We used ChIP-Seq to analyze the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.401.1