Epigenetic modification enzymes: catalytic mechanisms and inhibitors

Dioxygenase enzymes: catalytic mechanisms and chemical models

Catalytic Mechanisms of Glutamine Synthetase Enzymes

Glutamine synthetase enzymes isolated from pea seeds and from Escherichia coli are observed to behave differently in experiments designed to probe reaction mechanism. Although both enzymes were found to bind and release substrates in random order mechanisms (Wedler, F. C. (197415. Biol. Chem, 247, 5080-5087), isotopic exchanges with partial reaction systems indicative of a y-glutamylphosphate i...

TITLE : Development of Novel Inhibitors Targeting Epigenetic Enzymes

Introduction: The recently established field of epigenetics assists in filling the holes that cannot be answered by modern genetics. Epigenetics encompasses processes related to gene expression beyond the genetic code itself. It provides a comprehensive understanding that connects the environment, nutrition and heredity. In a direct link to human health, epigenetic changes are associated with c...

Unmasking catalytic reaction mechanisms: From small molecules to enzymes

In 1998 John Pople and Walter Kohn shared the Nobel Prize in Chemistry for the development of wave-function theory (WFT) and density-functional theory (DFT) methods, respectively. In 2013 the Chemistry Nobel Prize was awarded to Martin Karplus, Michael Levitt, and Arieh Warshel for the development of multi-scale methods. These electronic structure methods cover a wide range of accuracy and appl...

Catalytic antibodies and enzyme inhibitors

Catalytic antibodies or abzymes as we have termed them have generated an avalanche of "forecasts and predictions" concerning their future applications. This, because in principle their only limitations are the designer's creativity and one's ability to access the entire immune systems repertoire. Keeping these so-called predictions in mind, we have sought out a truly formidable test for our de ...