Epigenetic Control in Pituitary Tumors

Epigenetic control in pituitary tumors.

Epigenetically-mediated gene dysregulation is a common feature associated with human pituitary tumorigenesis. The mechanisms leading to these changes, however, remain largely unknown. In this review, we examine changes responsible for DNA and histone modifications as independent, butpotentially interrlated modes of communication effecting chromatin remodeling. The dynamic properties of the enzy...

Hormonal control of pituitary prolactin-secreting tumors.

Prolactin secreting adenomas (prolactinomas) are the most prevalent form of pituitary tumors in humans. Prolactinomas have been linked to estrogen exposure in humans and animals. However, the mechanism by which estrogen increases mitogenesis in lactotropes, as well as other estrogen responsive cells, is not well understood. Given the complex nature of steroid hormones and their wide array of ac...

Pituitary tumors.

Outcome of Transphenoid Surgery for Corticotroph Pituitary Tumors

Background & Importance: The aim of this study was to demonstrate the result of transsphenoid microsurgery for Cushing disease in our center and comparing the results in details with other articles, to achieve the best decision for patients management in future. Case Presentation: Between 1991 to 2015, 50 patients suffering from Cushing disease were operated. Before operation, endocrine t...

Pituitary tumors in the elderly.

The proportion of elderly subjects is growing in Western countries and, as a consequence, several diseases are now recognized with increasing frequency in the older segment of the population. Pituitary tumors are no exception to the rule. However, the presentation, diagnosis and management of pituitary tumors in the elderly, defined as patients older than 65 or 70 years depending on the differe...