منابع مشابه
Epigenetic Control Systems.
Advances in chemical genetics in the past few years have permitted the formulation of a consistent hypothesis concerning the chemical nature of the "primary" genetic material.1 This material is considered to consist of nucleic acid (usually deoxyribosenucleic acid) and to contain genetic information in a code of prescribed nucleotide sequences. The information is believed to be preserved during...
متن کاملOncogenic epigenetic control
contributes significantly to the fidelity of biological control. Compromised epigenetic pathways have now been shown to provide indications of transformation and tumor progression; they suggest potential targets for cancer prevention and intervention [1]. A formidable challenge is to deconvolute the complexity and plasticity of histone modifications associated with tumorigenesis. Although chall...
متن کاملVirus Control Goes Epigenetic
Cells have developed a number of mechanisms to detect and suppress microbial infections. The use of pattern recognition receptors (PRRs) is one such mechanism. PRRs may be expressed on the cell surface, in the cytosol, or in the endosomes, to detect pathogen-associated molecular patterns (PAMPs) or the danger signals released by damaged cells (i.e., damage-associated molecular patterns; DAMPs)....
متن کاملEpigenetic control of immunity.
Immunity relies on the heterogeneity of immune cells and their ability to respond to pathogen challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen receptor repertoire that matches the vast diversity of pathogens. In the innate immune system, the cell's heterogeneity and phenotypic plasticity enable flexible responses to changes in tissue homeostasis caused by ...
متن کاملControl of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms
Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide the biochemical basis for understanding latency. There are no specific repres...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2009
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.21678