Epigenetic Changes Predisposing to Type 2 Diabetes in Intrauterine Growth Retardation
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منابع مشابه
Epigenetic Changes Predisposing to Type 2 Diabetes in Intrauterine Growth Retardation
Epidemiologic studies have demonstrated an association between intrauterine growth retardation and a greater risk of chronic disease, including coronary heart disease, hypertension, stroke, and type 2 diabetes in adulthood. An adverse intrauterine environment may affect both growth and development of the organism, permanently programming endocrine and metabolic functions. One of the mechanisms ...
متن کاملIntrauterine growth retardation leads to the development of type 2 diabetes in the rat.
Intrauterine growth retardation has been linked to the development of type 2 diabetes in later life. The mechanisms underlying this phenomenon are unknown. We have developed a model of uteroplacental insufficiency, a common cause of intrauterine growth retardation, in the rat. Bilateral uterine artery ligation was performed on day 19 of gestation (term is 22 days) in the pregnant rat; sham-oper...
متن کاملDevelopment of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.
Intrauterine growth retardation (IUGR) has been linked to the onset of diseases in adulthood, including type 2 diabetes, and has been proposed to result from altered gene regulation patterns due to epigenetic modifications of developmental genes. To determine whether epigenetic modifications may play a role in the development of adult diabetes following IUGR, we used a rodent model of IUGR that...
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Epigenetics plays an important role in the fetal origins of adult disease. Intrauterine growth retardation (IUGR) can cause increased histone acetylation of the endothelin-1 (ET-1) gene from pulmonary vascular endothelial cells or the whole lung tissue and persist into later life, likely resulting in increased risk of pulmonary hypertension or asthma later in life. However, little is known rega...
متن کاملIntrauterine growth retardation.
The recognition that some low birthweight babies (<2500 g) were the victims of intrauterine growth retardation rather than premature birth was a milestone in perinatal medicine.'3 Up to 10% of all liveborn babies and at least 30% of those of low birth weight suffer from intrauterine growth retardation; their perinatal mortality is four to 10 times higher than that of normally grown babies-both ...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2010
ISSN: 1664-2392
DOI: 10.3389/fendo.2010.00005