Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level
نویسندگان
چکیده
منابع مشابه
Epigallocatechin-3-gallate protects HUVECs from PM2.5-induced oxidative stress injury by activating critical antioxidant pathways.
Endothelial dysfunction and oxidative stress likely play roles in PM2.5-induced harmful effects. Epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent of green tea, is a potent antioxidant that exerts protective effects on cardiovascular diseases (CVDs) in part by scavenging free radicals. The exposure to ambient fine particulate matter (PM2.5) is responsible for certain CVDs. T...
متن کاملEpigallocatechin-3-gallate protects against cisplatin nephrotoxicity by inhibiting the apoptosis in mouse.
Cisplatin (CP) is a commonly used anticancer drug, but its notable side effect of nephrotoxicity limits its use in clinic. Epigallocatechin-3-gallate (EGCG), an anti-oxidant, anti-inflammatory, and anti-tumorigenic green tea polyphenol, has been available on the market for its beneficial effects. The aim of this study was to investigate whether EGCG can prevent the nephrotoxic effect of CP and ...
متن کاملIntraperitoneal injection of (−)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina
PURPOSE (-)-epigallocatechin-3-gallate (EGCG), a major catechin component of green tea, is reported to delay or prevent certain forms of cancer, arthritis, cardiovascular disease, and neurodegenerative disorders. In this study, we determined if systemically administered EGCG could protect the retina against light damage (LD) in mice. METHODS BALB/cJ mice were treated with either EGCG or salin...
متن کامل(−)-Epigallocatechin-3-gallate (EGCG), a polyphenol, protects against sepsis-induced acute liver injury in rats
Sepsis is a significant public health problem and is one of the leading causes of death in critically ill patients admitted to the intensive care unit. Liver dysfunction occurs frequently in cases of sepsis. This study aims to investigate the protective effects of (−)-epigallocatechin-3-gallate (EGCG) on polymicrobial sepsis-induced acute liver injury and to explore the underlying mechanism. Se...
متن کاملAnticancer effects and molecular mechanisms of epigallocatechin-3-gallate
Epigallocatechin-3-gallate (EGCG) is a type of catechin found in green tea. EGCG exhibits a variety of activities, including anti-inflammatory, antidiabetes, antiobesity, and antitumor. In this review, we focus on the antitumor effects of EGCG. EGCG inhibits carcinogen activity, tumorigenesis, proliferation, and angiogenesis, and induces cell death. These effects are associated with modulation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 2010
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2010.05.011