Epidermal, Sebaceous, and Melanocytic Nevoid Proliferations Are Spectrums of Mosaic RASopathies
نویسندگان
چکیده
منابع مشابه
Tumorigenic Melanocytic Proliferations
The key role of histopathology in analysis of a melanocytic tumor is the recognition or exclusion of a malignant melanoma. The analysis of typical features leads to a correct diagnosis in the majority of cases. However, there are cases that are problematic, because of conflicting or insufficient criteria, in which a confident diagnosis is difficult. These difficult lesions account for a large p...
متن کاملTumorigenic Melanocytic Proliferations
The key role of histopathology in analysis of a melanocytic tumor is the recognition or exclusion of a malignant melanoma. The analysis of typical features leads to a correct diagnosis in the majority of cases. However, there are cases that are problematic, because of conflicting or insufficient criteria, in which a confident diagnosis is difficult. These difficult lesions account for a large p...
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Sebaceous lesions, including sebaceous hyperplasia, sebaceomas, and sebaceous adenomas and carcinomas, are histologically distinctive adnexal proliferations with a spectrum of biological behavior ranging from benign to frankly malignant. The histologic distinction between sebaceous adenomas and carcinomas may be challenging, especially in cases showing atypical features and in small or partial ...
متن کاملIndeterminate melanocytic proliferations of the conjunctiva.
PURPOSE The purpose of this study is to test the hypothesis that a subset of conjunctival melanocytic proliferations exists that cannot be reproducibly classified as benign, malignant, or indeterminate. METHODS Three groups of excisional biopsy specimens of conjunctival melanocytic proliferations were evaluated by 5 ophthalmic pathologists. These groups included lesions that were considered b...
متن کاملMelanocytic proliferations associated with lichen sclerosus.
OBJECTIVES To describe the clinicopathologic features of melanocytic proliferations associated with lichen sclerosus (LS) and to compare these findings with those in controls. DESIGN Cohort study. SETTING Academic and private practice dermatology and dermatopathology services. PATIENTS Cases of melanocytic proliferations associated with LS and consecutive controls with persistent (recurre...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2014
ISSN: 0022-202X
DOI: 10.1038/jid.2014.244