Epidemiological approaches to the immunogenetics of autoimmune rheumatic disease.
نویسندگان
چکیده
منابع مشابه
Epidemiological approaches to the immunogenetics of autoimmune rheumatic disease.
The familial clustering which occurs in certain autoimmune rheumatic diseases indicates an aetiological role for either shared genetic or shared environmental factors. Evidence implicating genetic factors in the aetiology of these diseases has come from the associations which have been described with specific antigens of the HLA system. These associations have a clear biological basis, given th...
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a Departamento de Inmunología y Reumatología de la Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico b Unidad de Investigación de Enfermedad Autoinmunes Sistémicas, Hospital General Regional #36 Instituto Mexicano del Seguro Social, Puebla, Mexico c Servicio de Alergología e Inmunología, Hospital Instituto de Seguridad y Servicios Sociales de los Trabajadores del E...
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Background/Objective: To clarify the state of different immunologic factors in patients with acute rheumatic fever (ARF) and rheumatic heart disease (RHD) compared to healthy individuals.Patients and Methods: Patients with ARF (#21), patients with RHD six months after the onset of ARF (#19), and healthy children from the same age group with normal physical examination and no history of pharyngi...
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Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potent...
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Vitiligo is a chronic disease characterized by the dysfunction or destruction of melanocytes with secondary depigmentation. The aim of the present study was to determine the prevalence of vitiligo associated with autoimmune rheumatic diseases. The clinical records from a 10-year database of patients with rheumatic diseases and associated vitiligo was analysed, with one group of patients having ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1993
ISSN: 0003-4967
DOI: 10.1136/ard.52.4.310