Epicardial Fat, Paracrine-mediated Inflammation and Atrial Fibrillation

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Epicardial Fat and Atrial Fibrillation: A Review.

Atrial fibrillation (AF) is a progressive disorder that increases with age. Obesity is an important risk factor for AF. Pericardial fat is an active adipose tissue in close proximity to the heart and has been shown to be a risk factor for structural as well as coronary artery disease independent of body mass index. Recent studies suggest a role of epicardial fat in atrial remodeling as well as ...

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Left atrial epicardial adiposity and atrial fibrillation.

BACKGROUND Atrial fibrillation (AF) has been linked to inflammatory factors and obesity. Epicardial fat is a source of several inflammatory mediators related to the development of coronary artery disease. We hypothesized that periatrial fat may have a similar role in the development of AF. METHODS AND RESULTS Left atrium (LA) epicardial fat pad thickness was measured in consecutive cardiac CT...

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Effect of epicardial fat pad ablation on acute atrial electrical remodeling and inducibility of atrial fibrillation.

BACKGROUND Atrial electrical remodeling (AER) is the underlying mechanism of atrial fibrillation (AF). The present study investigated the impact of epicardial fat pad (FP) ablation on acute AER (AAER) and inducibility of AF. METHODS AND RESULTS AAER was performed in 28 mongrel dogs through 4-h rapid atrial pacing (RAP). Before RAP, 14 dogs (ablation group) underwent FP ablation, and the other...

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Inflammation and atrial fibrillation.

trial fibrillation (AF) is a highly prevalent arrhythmia associated with significant morbidity and mortality because of the hemodynamic impairment and thromboembolic events. AF affects 1–1.5% of the population worldwide; it has been estimated that 2.2 million people in the USA and 4.5 million in Europe have paroxysmal or persistent AF. The estimated prevalence of AF was 0.6% in the Japanese gen...

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Epicardial adipose tissue and atrial fibrillation.

Atrial fibrillation (AF) is the most frequent cardiac arrhythmia in clinical practice. AF is often associated with profound functional and structural alterations of the atrial myocardium that compose its substrate. Recently, a relationship between the thickness of epicardial adipose tissue (EAT) and the incidence and severity of AF has been reported. Adipose tissue is a biologically active orga...

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ژورنال

عنوان ژورنال: Journal of Interdisciplinary Medicine

سال: 2017

ISSN: 2501-8132

DOI: 10.1515/jim-2017-0090