منابع مشابه
Ephs and ephrins
Eph receptors comprise the largest family of receptor tyrosine kinases (RTKs), with fourteen receptors divided into two subfamilies - EphAs and EphBs. Yet, despite their multitude of functions in almost all tissues of the body, these receptors represent one of the most underappreciated RTK families. What makes Eph receptors unique is that their cognate ligands, the ephrins, are tethered to the ...
متن کاملEditorial Editorial : Ephs , ephrins , and early T cell development
Introduction The development of self-tolerant, MHC-restricted T cells occurs in the thymus throughout the life of vertebrates. However, the thymus lacks precursors with self-renewal ability and is normally, continuously replenished with progenitors imported from the bone marrow [1]. The cross-talk between T cell progenitors and nonhematopoietic thymic stromal cells (thymic epithelial cells, end...
متن کاملThe Role of Ephs and Ephrins in Memory Formation
The ability to efficiently store memories in the brain is a fundamental process and its impairment is associated with multiple human mental disorders. Evidence indicates that long-term memory formation involves alterations of synaptic efficacy produced by modifications in neural transmission and morphology. The Eph receptors and their cognate ephrin ligands have been shown to be involved in the...
متن کاملEphs and Ephrins Keep Pancreatic β Cells Connected
The regulation of metabolic processes requires that cells communicate with their neighbors to ensure an appropriate response to the changing environment. The pancreas is a classic example of a tissue that depends on intercellular communication among the same (autocrine) and/or different (paracrine) cell types. The human pancreas is composed of over a million islets, each islet comprising severa...
متن کاملEditorial: Ephs, ephrins, and early T cell development.
Introduction The development of self-tolerant, MHC-restricted T cells occurs in the thymus throughout the life of vertebrates. However, the thymus lacks precursors with self-renewal ability and is normally, continuously replenished with progenitors imported from the bone marrow [1]. The cross-talk between T cell progenitors and nonhematopoietic thymic stromal cells (thymic epithelial cells, end...
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ژورنال
عنوان ژورنال: Growth Factors
سال: 2014
ISSN: 0897-7194,1029-2292
DOI: 10.3109/08977194.2014.985787