Ephrin-A5 deficiency alters sensorimotor and monoaminergic development
نویسندگان
چکیده
منابع مشابه
The role of ephrin-A2 and ephrin-A5 in sensorimotor control and gating.
Many factors influence neurodevelopment. However, their contribution to adult neural function is often unclear. This is often due to complex expression profiles, cell signalling, neuroanatomy, and a lack of effective tests to assess the function of neural circuits in vivo. Ephrin-A2 and ephrin-A5 are cell surface proteins implicated in multiple aspects of neurodevelopment. While the role of eph...
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Eph receptors and ephrin ligands are large families of cell surface proteins which have established roles in axonal growth and guidance. These are well characterized in the visual and somatosensory systems but are less well documented in the auditory pathway. We examined the possible functional role of two ephrin genes (ephrin-A2 and ephrin-A5) in the auditory system by measuring auditory brain...
متن کاملCellular localization of ephrin-A2, ephrin-A5, and other functional guidance cues underlies retinotopic development across species.
Avian retinotectal and rodent retinocollicular systems are general model systems used to examine developmental processes that underpin topographically organized neuronal circuits. The two systems rely on guidance components to establish their precise retinotopic maps, but many cellular events differ during their development. For example, compared with the chick, a generally less restricted outg...
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The Eph receptor tyrosine kinase/ephrin ligand system regulates a wide spectrum of physiological processes, while its dysregulation has been implicated in cancer progression. The human EphA3 receptor is widely upregulated in the tumor microenvironment and is highly expressed in some types of cancer cells. Furthermore, EphA3 is among the most highly mutated genes in lung cancer and it is also fr...
متن کاملEphrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development
BACKGROUND Synaptogenesis is a fundamental step in neuronal development. For spiny glutamatergic synapses in hippocampus and cortex, synaptogenesis involves adhesion of pre and postsynaptic membranes, delivery and anchorage of pre and postsynaptic structures including scaffolds such as PSD-95 and NMDA and AMPA receptors, which are glutamate-gated ion channels, as well as the morphological matur...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2013
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2012.08.032