منابع مشابه
Hepatic enzyme induction: histopathology.
Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal fluctuations, dietary constituents, infections ass...
متن کاملEnzyme induction and inhibition.
The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme systems. Similarly a wide range of drugs may produce clinically significan...
متن کاملPentobarbitone Distribution and Enzyme Induction
Sir,—Thank you for the opportunity of replying to the letter from Drs Bradshaw and Maddison. We can assume only that these workers have been unable to confirm our observations because of some fundamental difference in technique. The difference is not immediately apparent from the information provided in their letter, but several possibilities exist. First, our patients, who were not premedicate...
متن کاملEffects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction
Introduction: The main propose of this study was to determine the effect of parathion on activity of glutamate dehydrogenase (GDH) as a key enzyme in second phase secretion of insulin and to determine serum glucose levels in rats. Methods: To conduct the study, 35 rats were randomly divided into five groups (n=7). The serum glucose level of each group was measured and the total average was ca...
متن کاملInhibition by 2'-deoxyadenosine of enzyme induction in Pseudomonas testosteroni.
Among various systems in which induction of new enzyme synthesis can be initiated, that developed by Talalay,'-3 in which the metabolism of a variety of steroids by Pseudomonas testosieroni is induced by either testosterone or certain other steroidal compounds, has been particularly rewarding. Recent studies of this system by Wacker et al.4' 5 have suggested that a complex may be formed between...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1972
ISSN: 0007-0912
DOI: 10.1093/bja/44.9.961