منابع مشابه
Sites of enzyme activity along the nephron.
Renal tubular functions can be characterized as energy-consuming transport processes which are driven by metabolic energy-yielding reactions. In this context it has been argued that sodium transport is the major work function in mammalian kidney. Ullrich, Rumrich and Klöss have shown recently that in the absence of intraluminal sodium the transport of amino acids and hexoses approaches zero [1,...
متن کاملImmunolocalization of ectonucleotidases along the rat nephron.
Evidence is accumulating that extracellular nucleotides act as autocrine/paracrine agents in most tissues, including the kidneys. Several families of surface-located enzymes, collectively known as ectonucleotidases, can degrade nucleotides. Using immunohistochemistry, we have examined the segmental distribution of five ectonucleotidases along the rat nephron. Perfusion-fixed kidneys were obtain...
متن کاملDistribution of transporters along the mouse distal nephron: something old, something borrowed, something new.
THIS ISSUE OF the American Journal of Physiology: Renal Physiology contains two important papers describing the immunolocalization of transporters in the distal tubules of the mouse (3, 6). There are many reasons for the special interest in the organization of this region of the mouse nephron. The distal convoluted tubule (DCT) plays a critical role in regulating renal Na, Ca, and Mg excretion ...
متن کاملDistribution of cytochrome P-450 4A and 4F isoforms along the nephron in mice.
The production of 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney is thought to be involved in the control of renal vascular tone and tubular sodium and chloride reabsorption. 20-HETE production in the kidney has been extensively studied in rats and humans and occurs primarily via the actions of P-450 enzymes of the CYP4A and -4F families. Recent advancements in molecular genetics of th...
متن کاملDetermination of prostaglandin E2 synthesis along rabbit nephron by enzyme immunoassay.
Prostaglandin E2 (PGE2) content and synthesis have been measured in microdissected segments from the entire nephron of rabbit kidney. PGE2 was determined by an enzyme immunoassay on glomeruli or tubular segments (0.5-5 mm) either immediately after microdissection (PGE2 content) or after incubation for 15 min at 37 degrees C in the presence of arachidonic acid (PGE2 synthesis). We confirmed that...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1984
ISSN: 0085-2538
DOI: 10.1038/ki.1984.143