Enzymatic Synthesis of Resveratrol Oligosaccharides (Gluco-oligosaccharides) and their Enhanced Application as Antidementia Drugs that Cross the Blood-brain Barrier (BBB)

Enzymatic synthesis of oligosaccharides

The biological interest of oligosaccharides is growing very rapidly, and necessitates the development of efficient synthesis reactions. The stereoand regio-selectivity of enzyme catalysis is a key advantage in this field, as a complementary tool to the chemical approach. Two types of enzymes can be applied to the obtention of oligosaccharides: Hydrolytic enzymes, which can catalyze either rever...

The Enzymatic Synthesis and Disproportionation of Galactosyl Oligosaccharides

Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides.

This paper describes the study of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) regeneration from 3'-phosphoadenosine-5'-phosphate (PAP) for use in practical syntheses of carbohydrate sulfates which are catalyzed by sulfotransferases. Among the regeneration systems, the one with recombinant aryl sulfotransferase proved to be the most practical. This regeneration system was coupled with a sulfotr...

The mechanism of enzymatic synthesis of galactosyl oligosaccharides.

In recent publications, Wallenfels (1) and Aronson (2) have reported that new oligosaccharides are produced during the hydrolysis of lactose by enzyme preparations from bacteria and yeasts. The enzymatic synthesis of oligosaccharides from lactose has also been observed by Pazur (3) and by Roberts and McFarren (4). It has been suggested (l-3) that the new compounds are the result of transgalacto...

Synthesis of Capsaicin Oligosaccharides and Their Anti-Allergic Activity——Synthesis of Capsaicin Oligosaccharides as Anti-Allergic Food-Additives

The production of β-maltooligosaccharides of capsaicin was investigated using Lactobacillus delbrueckii and cyclodextrin glucanotransferase (CGTase) as biocatalysts. The cells of L. delbrueckii glucosylated capsaicin to give its β-glucoside. The β-glucoside of capsaicin was converted into the corresponding β-maltoside and β-maltotrioside by CGTase. On the other hand, β-melibioside and β-isomalt...