Enzymatic degradation of endothelin-1 by activated human polymorphonuclear neutrophils
نویسندگان
چکیده
منابع مشابه
The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.
The metabolism of big endothelin 1 (bET) and endothelin 1 (ET-1) by subcellular fractions from human polymorphonuclear leukocytes (PMNs) was investigated by bioassay and reversed-phase high-performance liquid chromatography. More than 80% of endothelin-converting activity was recovered from the cytosolic fraction, which in addition to ET-1 generated other peptides from bET. The processing of bE...
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ژورنال
عنوان ژورنال: Regulatory Peptides
سال: 1992
ISSN: 0167-0115
DOI: 10.1016/0167-0115(92)90021-l