Environmental cycles regulate development time via circadian clock mediated gating of adult emergence
نویسندگان
چکیده
منابع مشابه
Signs of the time: environmental input to the circadian clock.
The circadian clock forms one of the most fascinating adaptations to life on earth. Organisms can not only anticipate the day/night cycle but can make use of an internal clock to measure daylength as an indicator of the changing of the seasons. The innate period of the clock is not exactly equal to 24 h, but is reset each day by environmental signals at dawn and dusk, most notably by changes in...
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Circadian clock oscillation emerges in mouse embryo in the later developmental stages. Although circadian clock development is closely correlated with cellular differentiation, the mechanisms of its emergence during mammalian development are not well understood. Here, we demonstrate an essential role of the posttranscriptional regulation of Clock subsequent to the cellular differentiation for t...
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We have examined posttranslational regulation of clock proteins in mouse liver in vivo. The mouse PERIOD proteins (mPER1 and mPER2), CLOCK, and BMAL1 undergo robust circadian changes in phosphorylation. These proteins, the cryptochromes (mCRY1 and mCRY2), and casein kinase I epsilon (CKIepsilon) form multimeric complexes that are bound to DNA during negative transcriptional feedback. CLOCK:BMAL...
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Organisms utilize the circadian clock system to adapt to the predictable changes from day;night cycles. The circadian oscillator is based on transcription feedback loops in which alternate cycles of transcription activation and repression generate rhythmic accumulation of clock gene products and their downstream effectors of physiology. There is growing evidence that dynamic histone accumulatio...
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The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations, serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli and massive infiltration of leukocyt...
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2018
ISSN: 1471-213X
DOI: 10.1186/s12861-018-0180-6